Background: Schizophrenia being a debilitating illness leads to deterioration in occupational, interpersonal and self supporting abilities. This can pose numerous psychosocial difficulties for patients as well as family members who care for their loved ones resulting in burden of care. Due to the chronic stress of caring for these patients many caregivers develop psychiatric symptoms. Aims: This study was undertaken to assess the burden perceived by caregivers of schizophrenia patients, impact of socio-demographic and patient variables on perceived burden as well as the presence of psychological distress in the caregivers. Methods: 54 patients diagnosed as having schizophrenia as per the DSM IV TR with a duration of illness of two years or more and their caregivers were evaluated using the appropriate psychometric instruments to measure burden, anxiety and depression in caregivers. Results: Our study showed that overall burden perceived was 22.2% with no significant difference between the caregivers of either sex and burden perceived by the caregivers of the sample studied also had a significant impact on their anxiety and depression. Conclusion: Care-givers of schizophrenia patients experience burden as well as psychological distress secondary to caring for a relative with a chronic mental illness. Key message: Care-giver burden must be anticipated in schizophrenia patients and appropriate support must be provided.