Background-Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. The disease primarily affects lungs and causes pulmonary tuberculosis. Problem of tuberculosis is enormous and makes it a major public health problem in India. Under the Revised National Tuberculosis Control Program (RNTCP),priority is given to the smear positive cases. Every smear-positive person if left untreated has potential to infect 10-15 persons per year,therby inceasing the pool of infected persons. Material and methods :All the new sputum smear positive patients registered in Khammam TU during the second and third quarter of 2009 were enrolled as study subjects. A total of 413 patients were registered as per the inclusion criteria under six Designated Microscopic centers (DMCS). Results: A total of 413 patients were enrolled in the present study and followed up prospectively for complete duration of their treatment. Out of them 77 (18.04 %) were females and 336 (81.36%) were males. Of the total males in this study 0.59% was in the age group< 14 years and 24.7 % were in the age group of 35-44 years. Of the total females in this study 1.3% was in the the age group >65 years and 27.285 were in the age group of 15-24 years. Conclusion: Present disease cure rate of 85.47% should be improved by ensuring 100 % compliance in the treatment by continuous motivation and DOT providers need to be trained to motivate enrolled patients to go for regular periodic sputum follow up examination.