Aim to study the arterial variations in the arm. 100 upper limbs of 50 donated embalmed cadavers (45 males & 5 females) of age group ranging from 70 to 80 years were dissected in the department of Anatomy at K. J. Somaiya Medical College, Sion, Mumbai, India. The arterial variation in the arm was observed in 2 specimens. The neuro-mascular pattern in the arm was also observed. The photographs of the arterial variations in the arm were taken for proper documentation and ready reference. A double profunda brachii artery was found in in 2 specimens. The profunda brachii artery - 1 was originated from the posteromedial aspect of the brachial artery, distal to teres major muscle. The profunda brachii artery – 2 was originated from the posterior circumflex humeral artery in quadrangular space around the surgical neck of the humerus. The profunda brachii artery - 2 divided into the anterior descending (Radial collateral) & the posterior desending (middle collateral) arteries. The profunda brachii artery – 1 gives nutrient artery to the humerus and runs with posterior desending (middle collateral) artery & ends by anastomosing with interosseous recurrent artery behind the lateral epicondyle. The presence of double profunda brachii arteries in the radial groove may result in excessive haemorrhage during fractures. Topographical anatomy of the normal and abnormal variations of the brachial artery is clinically important for surgeons, orthopaedicians and radiologists performing angiographic studies on the upper limb.