Research Questions: Perception of the youths in Mumbai regarding HIV-AIDS and their attitude towards people with HIV. Settings: Colleges in city of Mumbai. Study Design: Cross-sectional observational type of study Participants: 237 youths of three junior colleges of Mumbai, India. Methodology: A structured questionnaire with a mix of open and closed ended questions was administered. Results: HIV-AIDS as a dangerous disease was perceived by 37%. At least one correct route of transmission was known to 96% students and 71% mentioned sexual route. Misconceptions regarding the route of transmission were prevailing amongst 19% of students. About 87% students gave at least one correct response on preventive measures with 34% emphasizing on use of condom. Forty two students felt that PLHA’s should be isolated to curb the spread of HIV. Reluctance to allow PLHA’s to live in the same building and share food was expressed by 22% and 32% students respectively.