Introduction: It is an undeniable reality that anatomy has a chief role to play in the practice of training doctors. It is a worldwide common belief that anatomy must be taught and learnt in such a way that it becomes clinically meaningful and is linked to the proficiency mandatory for new medical graduates. To facilitate clinical anatomy instructions, one method is to have regional anatomy taught by both anatomists as well as by clinicians. A study was conducted on 45 medical students admitted to the first MBBS course in the year 2014 at K J Somaiya Medical College. The aim of this study was to evaluate any difference in the level of knowledge of gross and clinical anatomy among first year MBBS students when taught by Anatomist alone Clinician alone and by both anatomist and clinician. In addition the student’s perception regarding the teaching method was estimated using a structured questionnaire. Our study confirmed the fact that the group taught by anatomist and clinician was the best. Conclusion: Anatomists and clinicians should identify core anatomical knowledge in a clinical context. They should set some strategy on an anatomy curriculum which they feel any independent medical practitioner must be acquainted with. A need based curriculum can be developed in each institute so as to arrange interactive sessions of preclinical and clinical teaching which will be more useful for the students in subsequent years.