PKD is an inherited condition defined by the pathological development of fluid-filled cysts throughout the kidneys leading to organ enlargement and chronic kidney disease. Autosomal dominant polycystic kidney disease (ADPKD) is the fourth commonest cause of kidney failure worldwide. The main feature of ADPKD is the presence of cystic tubules, which are unable to perform their function properly, resulting in fluid retention, high blood pressure and kidney failure. Eventually, there is slow progression to End Stage Renal Disease (ESRD). During routine dissection for undergraduate students, we came across a case of adult polycystic kidney disease in a 60-year-old male cadaver, who died of complications of the disease which included accelerated hypertension, and renal failure. The kidneys showed bilateral multiple simple cysts of varying sizes. The kidneys were enlarged with an increase in weight. Patients with polycystic kidney disease may live a normal lifespan without knowing that they have the disease. More typically, however, ADPKD causes progressive renal dysfunction often necessitating dialysis or renal transplant for survival. Individuals with ADPKD may present with extra-renal disease like Hypertension, liver cysts, kidney stones, cardiac valvular abnormalities etc. Lately there have been many preclinical and clinical trials in mechanism based therapeutics for the control of cyst formation. Knowledge of the preventable or alterable aspects can help the clinician to delay the progression of renal failure to a great extent.