During routine dissection, of the right upper limb of a 70 year old donated embalmed male cadaver in the Department of Anatomy, K.J. Somaiya Medical College, Sion, Mumbai, India, I observed a variant division of radial nerve in the lower part of the left arm. The radial nerve divided into three branches, a superficial branch of radial nerve (the radial nerve proper), a deep branch of the radial nerve (posterior interosseous nerve) and a nerve to the extensor carpi radialis brevis muscle. The arterial pattern of upper limb was normal. The variation was unilateral. The right upper limb was also normal. The photographs of the variations were taken for proper documentation. Conclusions. The awareness of the nerve supply to extensor carpi radialis brevis from the terminal branch of radial nerve is clinically important for surgeons dealing with entrapment or compressive neuropathies, orthopaedicians operating on the fractures of the lower end of the humerus, anesthetist performing pain management therapies on the upper limb and physiotherapist doing electromyography for evaluating and recording the electrical activity produced by skeletal muscles. A lack of knowledge of such type of variations might complicate surgical repair.