Introduction: Oxidative stress by producing lipid peroxidation products like oxidized Low Density Lipoprotein(LDL) acts as independent risk factor in ischemic stroke. When lipid peroxidation overwhelms antioxidative defense mechanism, it results in enhanced formation of oxidized LDL which promotes atherosclerosis. Human serum Paraoxanase (PON 1) which is an ester hydrolase synthesized in the liver prevents the oxidative modification of LDL. Aim: To investigate the level of oxidized LDL as oxidative stress marker and paraoxanase activity as an antioxidant enzyme in ischemic stroke patients and also the relation between Oxidized LDL level and CT findings in ischemic stroke patients. Materials and methods: The subjects in the study group comprised 40 ischemic stroke patients and 40 age and gender matched controls. Fasting plasma glucose, serum paraoxanase activity, plasma oxidized LDL level, fasting lipid profile were determined. Data analysed using SPSS version 16.0 Results: Ischemic stroke patients had significantly lower paraoxanase activity (<53kU/L), elevated levels of oxidized LDL(>2.26ug/ml), total cholesterol (>200mg%) and fasting glucose levels (>126mg%). Conclusion: Oxidized LDL level >2.26ug/ml, paraoxanase activity <53kU/L and FBS >126mg% were independent risk factor for stroke. Significantly higher levels of oxidized LDL were seen in patients with infarct in anterior circulation. This study implies that raised oxidized LDL and low serum paraoxanase activity are independent risk factors of ischemic stroke in patients with no other risk factors.